Cross-clade neutralization potential of the plasma of antiretroviral naïve HIV-1 infected children from north India
نویسندگان
چکیده
Methods We recruited 38 antiretroviral naïve HIV-1 infected children after getting written informed consent from their parents/guardians. The study was approved by the institute ethics committee. Neutralization efficiency of the patients’ plasma was tested against tier 2 pseudoviruses (3 clade C ZM53, Du172.17 and Du156.12 and 3 clade B RHPA4259.7, TRO.11 and SC422661.8) obtained from NIH AIDS Research and Reference Reagent Program by TZM-bl assay. The inhibitory dilution at 50% neutralization (ID50 titers) was determined by non-linear regression by the method of least squares. Correlation tests were carried out using Spearman rank correlation test.
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